Blocking effect of lyt-2 antibodies on T cell functions.

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Blocking effect of lyt-2 antibodies on T cell functions

Monoclonal anti-Lyt-2 antibodies blocked effector function of cytotoxic thymus-derived (T) cells in the absence of added complement. Cytolysis of both allogeneic cells and syngeneic lymphoma or sarcoma target cells was inhibited at the level of the effector lymphocytes. Anti-Lyt-1 and anti-Thy-1 antibodies did not block killer cells. Proliferation of T cells in mixed lymphocyte culture was also...

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Mouse alloantibodies capable of blocking cytotoxic T-cell function. I. Relationship between the antigen reactive with blocking antibodies and the Lyt-2 locus

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Susceptibility to Blocking by Lyt Antisera Clones: Specificity, Cell Surface Phenotype, and Characterization of Interleukin 2-dependent Cytotoxic T-Cell

Cytotox ic T-cel ls were derived from the per i toneal cavity of a C 5 7 B L / 6 mouse immunized with B A L B / c sarcoma Meth A and from the sp leens of B A L B / c x C 5 7 B L / 6 F1 (hereaf ter cal led CB6F1) mice immunized with B A L B / c leukemia R L ~ I . The cel ls were cu l tured in inter leukin 2 and c loned by limiting di lut ion, and their speci f ic i ty was determined by d i rect ...

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Effect of in vivo administration of Lyt antibodies. Lyt phenotype of T cells in lymphoid tissues and blocking of tumor rejection

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Characterization of interleukin 2-dependent cytotoxic T-cell clones: specificity, cell surface phenotype, and susceptibility to blocking by Lyt antisera.

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ژورنال

عنوان ژورنال: Journal of Experimental Medicine

سال: 1980

ISSN: 0022-1007,1540-9538

DOI: 10.1084/jem.152.3.674